Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins
1996/03/25 by Holger Kayser, Hans Meisel · 203 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Amino acid #Biochemical effects in animals #Biochemistry #Biology #Chemistry #DNA synthesis #Endocrinology #In vitro #Internal medicine #Leucine #Medicine #Molecular biology #Neuropeptides and Animal Physiology #Peptide #Protein Hydrolysis and Bioactive Peptides #Stimulation
paper · pdf · doi:10.1016/0014-5793(96)00207-4
published in FEBS Letters 383(1-2), 18-20 (Wiley)
openalex publication_date 1996/03/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Abstract
The in vitro modulation of the proliferation of human peripheral blood lymphocytes by different synthetic peptides derived from milk proteins was investigated. Therefore, proliferation changes were followed up after incorporation of BrdU into the DNA, and the influence on protein biosynthesis was measured using the [3H]leucine incorporation test. Tyr-Gly and Tyr-Gly-Gly significantly enhanced (maximal 90 and 35%, respectively) the proliferation of PBL. For beta-casomorphin-7 and beta-casomorphin-10,lymphocyte proliferation was suppressed at lower concentrations, but stimulated at higher concentrations (> or = 10(-7) mol/l). Protein synthesis was stimulated (maxima at 25%) only with Tyr-Gly and Tyr-Gly-Gly. The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds.
Cited by
- Bioactive Milk Peptides: A Prospectus
- Synthesis and application of dipeptides; current status and perspectives
- Chickpea protein hydrolysate as a substitute for serum in cell culture. [europepmc]
- Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows. [europepmc]
- Peptidomic profile of milk of Holstein cows at peak lactation. [europepmc]
- Milk Intolerance, Beta-Casein and Lactose. [europepmc]
- Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows' milk. [europepmc]
- Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines. [europepmc]
- Cheese as Functional Food: The Example of Parmigiano Reggiano and Grana Padano. [europepmc]
- Milk Fermented by Specific Lactobacillus Strains Regulates the Serum Levels of IL-6, TNF-α and IL-10 Cytokines in a LPS-Stimulated Murine Model. [europepmc]
- Peptidomic and glycomic profiling of commercial dairy products: identification, quantification and potential bioactivities. [europepmc]
- Casein and Peptides Derived from Casein as Antileukaemic Agents. [europepmc]
- In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides. [europepmc]
- Exploring Potential Bioactive Peptides in Fermented Bactrian Camel's Milk and Mare's Milk Made by Mongolian Nomads. [europepmc]
- Novel Leu-Val Based Dipeptide as Antimicrobial and Antimalarial Agents: Synthesis and Molecular Docking. [europepmc]
- Breastfeeding importance and its therapeutic potential against SARS-CoV-2. [europepmc]
- Calcium Solubilization Ability and Anti-Inflammatory Effects of Hydrolyzed Casein. [europepmc]
- Enhancement of Anti-Tumoral Immunity by β-Casomorphin-7 Inhibits Cancer Development and Metastasis of Colorectal Cancer. [europepmc]
- Beneficial Effects of Vitamins, Minerals, and Bioactive Peptides on Strengthening the Immune System Against COVID-19 and the Role of Cow's Milk in the Supply of These Nutrients. [europepmc]
- Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action. [europepmc]
- In Vitro Anti-Inflammatory Activity of Peptides Obtained by Tryptic Shaving of Surface Proteins of Streptococcus thermophilus LMD-9. [europepmc]
- Role of milk glycome in prevention, treatment, and recovery of COVID-19. [europepmc]
- Preventative and therapeutic potential of animal milk components against COVID-19: A comprehensive review. [europepmc]
- Bioactive milk peptides: an updated comprehensive overview and database. [europepmc]
- Plant-Derived Proteins and Peptides as Potential Immunomodulators. [europepmc]
- Milk Antiviral Proteins and Derived Peptides against Zoonoses. [europepmc]
- Effects of A1 Milk, A2 Milk and the Opioid-like Peptide β-Casomorphin-7 on the Proliferation of Human Peripheral Blood Mononuclear Cells. [europepmc]
Related