2011/03/28 by Alexander Gersten, Gersten, Alexander
Biochemistry, Genetics and Molecular Biology · Medicine · #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Medical Physics (physics.med-ph) #Optical Imaging and Spectroscopy Techniques #S100 Proteins and Annexins #Traumatic Brain Injury and Neurovascular Disturbances
paper · pdf · doi:10.48550/arxiv.1103.5491
openalex publication_date 2011/03/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Among the major factors controlling the cerebral blood flow (CBF), the effect of PaCO2 is peculiar in that it violates autoregulatory CBF mechanisms and allows to explore the full range of the CBF. This research resulted in a simple physical model, with a four parameter formula, relating the CBF to PaCO2. The parameters can be extracted in an easy manner, directly from the experimental data. With this model earlier experimental data sets of Rhesus monkeys and rats were well fitted. Human data were also fitted with this model. Exact formulae were found, which can be used to transform the fits of one animal to the fits of another one. The merit of this transformation is that it enable us the use of rats data as monkeys data simply by rescaling the PaCO2 values and the CBF data. This transformation makes possible the use of experimental animal data instead of human ones.