1999/11/14 by A. Gersten, Gersten, A.
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Physical sciences #Medical Physics (physics.med-ph) #Quantitative Biology (q-bio) #physics.bio-ph #physics.med-ph #q-bio
paper · pdf · doi:10.48550/arxiv.physics/9911029
27 pages
arxiv created 2005/01/09 · arxiv updated 2009/12/01
Among the major factors controlling the cerebral blood flow (CBF) - cerebral perfusion pressure, arterial partial pressure of oxygen (PaO2), cerebral metabolism, arterial partial pressure of carbon dioxide (PaCO2), and cardiac output, the effect of PaCO2 is peculiar in being independent of autoregulatory CBF mechanisms and it allows to explore the full range of the CBF. We have developed a simple physical model, and have derived a simple four parameter formula, relating the CBF to PaCO2. The parameters can be extracted in an easy way, directly from the experimental data. With this model five experimental data sets of human, rats, baboons and dogs were well fitted. The same type of parametrization was also used successfully for fitting experimental data of PaO2 of dogs. We have also looked on the dependence of the parameters on other factors and were able to evaluate their dependence on the mean arterial blood pressure.