2015/06/13 by Giuseppe Mazza, Paolo De Coppi, Paul Gissen +1 · 1 citation
Medicine · #Liver physiology and pathology #Xenotransplantation and immune response #Tissue Engineering and Regenerative Medicine #Regenerative medicine #Medicine #Biology #Cell biology #Stem cell
paper · doi:10.1016/j.jhep.2015.05.001
openalex publication_date 2015/06/13 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/26
The first human liver transplantation was performed by Thomas Starzl in 1963. Orthotopic liver transplantation (OLT) has evolved dramatically over the past 50years and it is now established as a definitive treatment of most types of liver failure [1]. However, whole organ transplantation is mostly limited by the unavailability of a sufficient number of suitable donor organs. Therefore, other approaches such as hepatocyte transplantation and tissue engineering represent an area of intense investigation.