2011/01/01 by Vibha Varma, Naimish Mehta, Vinay Kumaran +1 · 2 citations
Medicine · #Liver Disease and Transplantation #Organ Transplantation Techniques and Outcomes #Liver Disease Diagnosis and Treatment #Medicine #Liver transplantation #Immunosuppression #Economic shortage #Abstinence #Transplantation #Alcoholic liver disease #Intensive care medicine #Liver disease #Acute hepatic failure #Surgery #Liver failure #Cirrhosis #Internal medicine
paper · pdf · doi:10.4061/2011/121862
openalex publication_date 2011/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Patients with chronic liver disease and certain patients with acute liver failure require liver transplantation as a life-saving measure. Liver transplantation has undergone major improvements, with better selection of candidates for transplantation and allocation of scarce deceased donor organs (according to more objective criteria). Living donor liver transplantation came into existence to overcome the shortage of donor organs especially in countries where there was virtually no deceased donor programme. Advances in the technical aspects of the procedure, the intraoperative and postoperative care of both recipients and donors, coupled with the introduction of better immunosuppression protocols, have led to graft and patient survivals of over 90% in most high volume centres. Controversial areas like transplantation in alcoholic liver disease without abstinence, acute alcoholic hepatitis, and retransplantation for recurrent hepatitis C virus infection require continuing discussion.