2007/06/26 by Christian Lange, Michael Dürr, Hong Doster +2 · 1 citation
Immunology and Microbiology · #Immunotherapy and Immune Responses #T-cell and B-cell Immunology #Immune Cell Function and Interaction #Peripheral tolerance #Immune system #Biology #Dendritic cell #Immune tolerance #Immunology #Immunity #Cell biology #T cell #Downregulation and upregulation #Gene #Genetics
paper · doi:10.1038/sj.icb.7100088
openalex publication_date 2007/06/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
In addition to their immunostimulatory capacity, dendritic cells (DCs) play a crucial role in central and peripheral tolerance mechanisms. In the absence of an infection, immature DCs constantly take up, process and present self-antigens to specific T cells, which leads to the induction of T-cell anergy or deletion. In recent years, several additional mechanisms have been identified by which DCs constantly downregulate immune responses to maintain immunological tolerance. Among these are the complex interactions between several DC subtypes and different types of regulatory T cells. In this review, we summarize recent key findings and concepts in this field.