A forkhead-domain gene is mutated in a severe speech and language disorder

2001/10/04 by Cecilia S. L. Lai, Cecilia Lai, Simon E. Fisher +4 · 4 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · #Biology #Breakpoint #Chromosomal translocation #Developmental psychology #FOXP2 #Forkhead Transcription Factors #Gene #Genetics #Genetics and Neurodevelopmental Disorders #Genomics and Chromatin Dynamics #Language disorder #Locus (genetics) #Neuroscience #Psychology #RNA modifications and cancer #Specific language impairment #Transcription factor

paper · pdf · doi:10.1038/35097076

crossref issued 2001/10/04 · crossref published 2001/10/04 · crossref published-print 2001/10/04 · openalex publication_date 2001/10/04 · crossref created 2002/07/26 · crossref deposited 2024/01/03 · openalex created_date 2025/10/10 · crossref indexed 2026/07/24 · openalex updated_date 2026/08/04

Citations

• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Cited by

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• Developmental mechanisms: putting genes in their place
• Australian zebra finch [wikipedia]