2018/10/30 by Bowen Zheng, Hui Shen, Hedong Han +2 · 1 citation
Medicine · Nursing · #Ovarian cancer diagnosis and treatment #Food composition and properties #Cancer Risks and Factors #Medicine #Ovarian cancer #Meta-analysis #Confounding #Relative risk #Internal medicine #Confidence interval #Cancer #Oncology #Prospective cohort study #Epidemiology #Physiology #Gynecology
paper · pdf · doi:10.1186/s12937-018-0407-1
openalex publication_date 2018/10/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
BACKGROUND: Epidemiological studies regarding the association between dietary fiber intake and ovarian cancer risk are still inconsistent. We aimed to review the available evidence and conduct a dose-response meta-analysis to investigate the relationship between dietary fiber intake and ovarian cancer risk. METHODS: Relevant studies were identified by searching PubMed, EMBASE, and the Cochrane Library databases before August 2017. Studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between dietary fiber intake and risk of ovarian cancer were included. Random-effects models were used to combine the estimated effects extracted from individual study. RESULTS: = 4.20%, P = 0.40). Our dose-response analysis also showed a significant inverse association between dietary fiber intake and ovarian cancer risk (an increment of 10 g/day; combined RR: 0.88; 95% CI: 0.82, 0.93). There was no evidence for a nonlinear association (P for nonlinearity = 0.83). CONCLUSIONS: This meta-analysis suggests a significant inverse dose-response association between dietary fiber intake and ovarian cancer risk. Further studies with prospective design that take account of more potential confounders are warranted to confirm this association.