2010/10/07 by Anita Raj · 4 citations
Health Professions · Medicine · #Adolescent Sexual and Reproductive Health #Allergy #Asthma #Atopic dermatitis #Atopy #Child and Adolescent Health #Dermatology #Food allergy #Immunology #Medicine #Pregnancy and Medication Impact #Skin barrier #Thymic stromal lymphopoietin
paper · doi:10.1136/adc.2009.178707
openalex publication_date 2010/10/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
It has long been observed that the development of asthma, allergic rhinitis and food allergy are frequently preceded by atopic dermatitis, a phenomenon known as the “atopic march”. Clinical, genetic and experimental studies have supported the fact that atopic dermatitis could be the initial step of the atopic march, leading to the subsequent development of other atopic diseases. This brief review will focus on the current evidence showing that epidermal barrier dysfunction and the keratinocyte-derived cytokine thymic stromal lymphopoietin play critical roles in the onset of the atopic march.