How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?

2017/03/23 by D’Maris Amick Dempsey, Daniel F. Klessig · 1 citation
Agricultural and Biological Sciences · #Plant-Microbe Interactions and Immunity #Plant pathogens and resistance mechanisms #Fungal Plant Pathogen Control #Biology #Salicylic acid #Effector #Hormone #Receptor #Plant hormone #Plant defense against herbivory #Plant Immunity #Disease #Cell biology #Plant growth #Biochemistry #Botany #Arabidopsis #Internal medicine #Gene

paper · pdf · doi:10.1186/s12915-017-0364-8

openalex publication_date 2017/03/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

Salicylic acid (SA) is an important plant hormone that regulates many aspects of plant growth and development, as well as resistance to (a)biotic stress. Efforts to identify SA effector proteins have revealed that SA binds to and alters the activity of multiple plant proteins-this represents a shift from the paradigm that hormones mediate their functions via one or a few receptors. SA and its derivatives also have multiple targets in animals; some of these proteins, like their plant counterparts, are associated with pathological processes. Together, these findings suggest that SA exerts its defense-associated effects in both kingdoms via a large number of targets.

Citations

• Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
• Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
• Estimates of benefits and harms of prophylactic use of aspirin in the general population
• Salicylic acid beyond defence: its role in plant growth and development
• Role of Salicylic Acid in Plants
• Salicylic acid signaling in disease resistance
• Salicylic Acid, a Multifaceted Hormone to Combat Disease
• Priming for Enhanced Defense

Cited by

• Plant hormone [wikipedia]