Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971/06/01 by John R. Vane, J. R. VANE · 24 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Eicosanoids and Hypertension Pharmacology #Inflammatory mediators and NSAID effects #Pharmacogenetics and Drug Metabolism

paper · doi:10.1038/newbio231232a0

crossref issued 1971/06/01 · crossref published 1971/06/01 · crossref published-print 1971/06/01 · openalex publication_date 1971/06/01 · crossref created 2013/07/23 · crossref deposited 2025/04/30 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/01

Cited by

• Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?
• 15-epi-lipoxin A4–mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation
• Fever
• COX-2 Inhibitors and Cardiovascular Risk
• Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells
• The mechanism of action of aspirin
• Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans
• Over-the-counter analgesics and antipyretics: A critical assessment
• The real dimension of analgesic activity of aspirin
• Salicylate Induces Tinnitus through Activation of Cochlear NMDA Receptors
• Nonsteroidal Anti‐inflammatory Drug‐Induced Reactions and Desensitization
• Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself?
• Cyclooxygenases: structural and functional insights
• Prostaglandins in Health and Disease: An Overview
• Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain
• Non-redundant Functions of Cyclooxygenases: Oxygenation of Endocannabinoids
• Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity
• Antipyretics: mechanisms of action and clinical use in fever suppression
• A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase
• Why are non-steroidal anti-inflammatory drugs so variable in their efficacy? A description of ion trapping.
• Ischaemia-reperfusion injury
• How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?
• Effects of Gum acacia aqueous extract on the histology of the intestine and enzymes of both the intestine and the pancreas of albino rats treated with Meloxicam
• Aspirin [wikipedia]