2014/07/23 by Qing Qu, Wenjuan Xuan, Guo‐Huang Fan · 1 citation
Nursing · Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Fatty Acid Research and Health #Eicosanoids and Hypertension Pharmacology #Advanced Glycation End Products research #Inflammation #Lipid signaling #Inflammatory response #Endogeny #Biology #Immunology #Computational biology #Neuroscience #Bioinformatics #Medicine #Biochemistry
paper · doi:10.1002/cbin.10345
openalex publication_date 2014/07/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Resolution is an active process that terminates inflammatory response to maintain health. Acute inflammation and its timely resolution are important in host response to danger signals. Unresolved inflammation is associated with widely recurrent diseases. Resolvins, including the D and E series, are endogenous lipid mediators generated during the resolution phase of acute of inflammation from the ω-3 PUFAs, DHA, and EPA. They have anti-inflammatory and pro-resolving properties that have been determined in many inflammation studies in animal models. In this review, we provide an updated overview of biosynthesis, actions, and signaling pathways of resolvins, thereby underscoring their diverse protective roles and introducing novel therapeutic strategies for inflammation-associated diseases.