2019/01/01 by Luke J. Archibald · 1 citation
Medicine · Neuroscience · Psychology · #Schizophrenia research and treatment #Neurotransmitter Receptor Influence on Behavior #Obsessive-Compulsive Spectrum Disorders #Schizoaffective disorder #Schizophrenia (object-oriented programming) #Alcohol use disorder #Psychiatry #Schizophrenia spectrum #Bipolar disorder #Etiology #Intervention (counseling) #Psychology #Clinical psychology #Spectrum disorder #Medicine #Psychosis #Alcohol #Cognition
paper · pdf · doi:10.35946/arcr.v40.1.06
openalex publication_date 2019/01/01 · openalex created_date 2019/09/19 · openalex updated_date 2026/08/01
Schizophrenia and schizoaffective disorder are schizophrenia spectrum disorders that cause significant disability. Among individuals who have schizophrenia or schizoaffective disorder, alcohol use disorder (AUD) is common, and it contributes to worse outcomes than for those who do not have co-occurring substance use disorder. Common neurobiological mechanisms, including dysfunction in brain reward circuitry, may explain the high rates of co-occurrence of schizophrenia and AUD or other substance use disorders. Optimal treatment combines pharmacologic intervention and other therapeutic modalities to address both the psychotic disorder and AUD. Further research on the etiology of these co-occurring disorders and on treatment of affected individuals is needed.