Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

2007/01/17 by Darwyn Kobasa, Steven M. Jones, Kyoko Shinya +15 · 7 citations
Immunology and Microbiology · Medicine · #Biology #Coronavirus disease 2019 (COVID-19) #Disease #Gene #Genetics #Immune Response and Inflammation #Immune system #Immunology #Infectious disease (medical specialty) #Influenza A virus #Influenza A virus subtype H5N1 #Influenza Virus Research Studies #Innate immune system #Macaque #Medicine #Pandemic #Phenotype #Virology #Virulence #Virus #interferon and immune responses

paper · pdf · doi:10.1038/nature05495

openalex publication_date 2007/01/17 · crossref created 2007/01/17 · crossref issued 2007/01/18 · crossref published 2007/01/18 · crossref published-print 2007/01/18 · crossref deposited 2025/04/10 · openalex created_date 2025/10/10 · crossref indexed 2026/07/23 · openalex updated_date 2026/08/04

Citations

• Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus
• Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
• Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus
• A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

Cited by

• Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors
• Salicylates and Pandemic Influenza Mortality, 1918–1919 Pharmacology, Pathology, and Historic Evidence
• Secondary Bacterial Infections Associated with Influenza Pandemics
• The origins of the great pandemic
• Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
• Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes
• Spanish flu [wikipedia]