Some Factors Affecting the Time Course of the Recovery of Contracture Ability Following a Potassium Contracture in Frog Striated Muscle

1965/07/01 by John V. Milligan, C. Edwards · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Ion channel regulation and function #Cardiomyopathy and Myosin Studies #Contracture #Potassium #Calcium #Chemistry #Biophysics #Anesthesia #Internal medicine #Surgery #Medicine #Biology

paper · pdf · doi:10.1085/jgp.48.6.975

openalex publication_date 1965/07/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/02

Abstract

Voltage clamp measurements on squid giant axons show that externally applied puffer fish poison, tetrodotoxin, eliminates only the initial inward current component of spike electrogenesis and does not affect the subsequent outward current. The selective effect on Na activation, which is reversible, confirms the view that the movements of Na and K during spike electrogenesis occur at structurally different sites on the membrane. Spike electrogenesis is also blocked when tetrodotoxin is injected into the axon, but the interior of the membrane appears to be somewhat less sensitive to the poison. Differences in reactivity of various electrogenic membrane components to tetrodotoxin are discussed as signifying differences in chemical structures.

Citations

• A quantitative description of membrane current and its application to conduction and excitation in nerve
• Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons

Cited by

• The binding of saxitoxin and tetrodotoxin to excitable tissue
• Correlation of Transmitter Release with Membrane Properties of the Presynaptic Fiber of the Squid Giant Synapse
• Action potential [wikipedia]