2010/01/01 by Perrine Broy, Anick Bérard · 1 citation
Medicine · #Maternal Mental Health During Pregnancy and Postpartum #Reproductive Health and Contraception #Menstrual Health and Disorders #Venlafaxine #Paroxetine #Medicine #Mirtazapine #Bupropion #Abortion #Antidepressant #Pregnancy #Obstetrics #Fluoxetine #Mianserin #Gestation #Prospective cohort study #Cohort study #Adverse effect #Psychiatry #Internal medicine #Anxiety #Serotonin
paper · doi:10.2174/156720110790396508
openalex publication_date 2010/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
BACKGROUND: Although the relationship between antidepressant use during pregnancy and its adverse effects has been widely investigated, very few studies have evaluated the impact of antidepressant use during pregnancy on the risk of spontaneous abortion. We present an overview of the evidence relating to the association between antidepressant use during gestation and the risk of spontaneous abortion. METHODS: We systematically searched PubMed and the reference lists of all relevant articles, including reviews, published in English or French from 1975 through 2009 for studies that examined the association between adverse pregnancy outcomes and gestational exposure to antidepressants with data on spontaneous abortions. Only etiologic studies were considered. RESULTS: Fifteen studies met inclusion criteria. The majority of these were prospective cohort studies on tricyclics antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs) use during pregnancy. Overall, in unadjusted analyses, fluoxetine (OR = 2.0; 95% CI = 1.4 - 3.0) and bupropion (OR = 4.1; 95% CI = 1.5 - 11.1) were significantly associated with the risk of spontaneous abortion. However, in adjusted analyses, only paroxetine (OR = 1.7; 95% CI = 1.3 - 2.3) and venlafaxine (OR = 2.1; 95% CI = 1.3 - 3.3) were significantly associated with the risk of spontaneous abortion. CONCLUSIONS: This review suggests that gestational exposure to antidepressants, especially paroxetine and venlafaxine, can lead to spontaneous abortion.