2005/11/01 by Kimberly A. Yonkers, Katherine A. Blackwell, Janis Glover +2 · 2 citations
Medicine · Social Sciences · #Adverse effect #Antidepressant #Anxiety #Cardiovascular Issues in Pregnancy #Community college #Confounding #Depression (economics) #Fetus #Gestation #Higher Education Governance and Development #Higher Education Learning Practices #Higher Education Research Studies #In utero #Internal medicine #Maternal Mental Health During Pregnancy and Postpartum #Medical education #Medicine #Obstetrics #Paroxetine #Pedagogy #Political science #Pregnancy #Pregnancy and Medication Impact #Psychiatry #Public relations #Qualitative research #Social science #Sociology #Teratology
paper · pdf · doi:10.1146/annurev-clinpsy-032813-153626
openalex publication_date 2005/11/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Women in their reproductive years are at risk of experiencing depressive and anxiety disorders. As such, it is likely that pregnant women will undergo treatment with antidepressants. We review the risk of adverse birth outcomes and neonatal complications subsequent to antidepressant use in pregnancy. An inconsistent literature shows that antidepressant exposure is associated with shortened gestations and diminished fetal growth; these effects are small. Transitory neonatal signs are seen in some neonates after exposure to antidepressants in utero. No specific pattern of malformations has been consistently associated with antidepressants, with the possible exception of paroxetine and cardiac malformations. There is inconclusive evidence of a link between antidepressants in late pregnancy and persistent pulmonary hypertension in the newborn. Extensive study finds that antidepressants cannot be considered major teratogens. It is likely that confounding factors contribute to a number of the adverse effects found to be associated with antidepressant use in pregnancy.