1997/08/01 by İclal Çakıcı, Hediye Y Ulug, Sibel İnci +4 · 2 citations
Chemistry · Psychology · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Chemical synthesis and alkaloids #Psychedelics and Drug Studies #Alkaloids: synthesis and pharmacology #Amaryllidaceae #Nociception #Pharmacology #Traditional medicine #Medicine #Biology #Botany #Internal medicine #Receptor
paper · pdf · doi:10.1111/j.2042-7158.1997.tb06121.x
openalex publication_date 1997/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The antinociceptive effects of ethanolic extracts of Pancratium maritimum L., Narcissus tazetta subspecies tazetta and Leucojum aestivum L. bulbs have been investigated in mice using the p-benzoquinone-induced abdominal constriction and hot-plate tests. In the p-benzoquinone-induced abdominal constriction test the ethanolic extracts of P. maritimum (300, 600 or 1200 mg kg-1, s.c.) and N. tazetta subsp. tazetta (5, 50, 100 or 200 mg kg-1, s.c.) caused dose-dependent inhibition of abdominal constrictions whereas a fluctuating response was obtained from ethanolic extracts of L aestivum (2.5-500 mg kg-1, s.c.). In the hot-plate test P. maritimum and L. aestivum caused a significant increase of latency only at the highest concentrations used (1200 mg kg-1 and 500 mg kg-1, i.p., respectively). However, at these concentrations they also caused significant toxic effects. In contrast with P. maritimum and L. aestivum, N. tazetta subsp. tazetta (5-500 mg kg-1, i.p.) extracts had no antinociceptive effect in this test. These findings indicate that the antinociceptive effect of Amaryllidaceae plants differs depending on the model of nociception investigated.