Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.

1993/05/01 by Koichiro Tamura, M Nei · 55 citations
Biochemistry, Genetics and Molecular Biology · #Metabolism and Genetic Disorders #Genomics and Phylogenetic Studies #Mitochondrial Function and Pathology #Transversion #Biology #Mitochondrial DNA #mtDNA control region #Genetics #Nucleotide #Transition (genetics) #Substitution (logic) #Evolutionary biology #Molecular clock #Phylogenetics #Mutation #Gene #Haplotype #Genotype

paper · pdf · doi:10.1093/oxfordjournals.molbev.a040023

openalex publication_date 1993/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transversional substitutions per site, as well as the total number of nucleotide substitutions. In this method, excess transitions, unequal nucleotide frequencies, and variation of substitution rate among different sites are all taken into account. Application of this method to human and chimpanzee data suggested that the transition/transversion ratio for the entire control region was approximately 15 and nearly the same for the two species. The 95% confidence interval of the age of the common ancestral mtDNA was estimated to be 80,000-480,000 years in humans and 0.57-2.72 Myr in common chimpanzees.

Citations

• Dating of the human-ape splitting by a molecular clock of mitochondrial DNA
• Pedagogical Reflections from an Instructional TechnologyWorkshop.
• A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
• The neighbor-joining method: a new method for reconstructing phylogenetic trees.
• On the genealogy of large populations

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