2017/12/20 by Giovanni Paolino, Michele Donati, Dario Didona +2 · 1 citation
Medicine · #Nonmelanoma Skin Cancer Studies #Cutaneous Melanoma Detection and Management #Cancer and Skin Lesions #Histology #Melanoma #Medicine #Pathology #Skin cancer #Cancer #Internal medicine #Cancer research
paper · pdf · doi:10.3390/biomedicines5040071
openalex publication_date 2017/12/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Non-melanoma skin cancer (NMSC) is the most frequently diagnosed cancer in humans. Several different non-melanoma skin cancers have been reported in the literature, with several histologic variants that frequently cause important differential diagnoses with other cutaneous tumors basal cell carcinoma (BCC) is the most common malignant skin tumor, with different histologic variants that are associated with a greater or less aggressive behavior and that usually may be confused with other primitive skin tumors. Actinic keratosis, Bowen's disease, keratoacanthoma, and invasive squamous cell carcinoma (SCC) correspond to the other line of NMSC, that may have only local tumoral behavior, easy to treat and with local management (as in the case of actinic keratosis (AK), Bowen's disease, and keratoacanthoma) or a more aggressive behavior with a potential metastatic spread, as in case of invasive SCC. Therefore, histopathology serves as the gold standard during daily clinical practice, in order to improve the therapeutical approaches to patients with NMSC and to understand the distinct histopathological features of NMSC. Here, we reported the main pathological features of different non-melanoma skin cancers.