2016/02/17 by Karen Sugden, Terrie E. Moffitt, Lauriane Pinto +3 · 2 citations
Immunology and Microbiology · Neuroscience · Medicine · Psychology · #Toxoplasma gondii Research Studies #Tryptophan and brain disorders #Autoimmune Neurological Disorders and Treatments #Toxoplasma gondii #Neurocognitive #Population #Cohort #Impulsivity #Psychiatry #Medicine #Schizophrenia (object-oriented programming) #Neuropsychology #Psychology #Clinical psychology #Immunology #Cognition #Internal medicine
paper · pdf · doi:10.1371/journal.pone.0148435
openalex publication_date 2016/02/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
BACKGROUND: Toxoplasma gondii (T. gondii) is a protozoan parasite present in around a third of the human population. Infected individuals are commonly asymptomatic, though recent reports have suggested that infection might influence aspects of the host's behavior. In particular, Toxoplasma infection has been linked to schizophrenia, suicide attempt, differences in aspects of personality and poorer neurocognitive performance. However, these studies are often conducted in clinical samples or convenience samples. METHODS/RESULTS: In a population-representative birth-cohort of individuals tested for presence of antibodies to T. gondii (N = 837) we investigated the association between infection and four facets of human behavior: neuropsychiatric disorder (schizophrenia and major depression), poor impulse control (suicidal behavior and criminality), personality, and neurocognitive performance. Suicide attempt was marginally more frequent among individuals with T. gondii seropositivity (p = .06). Seropositive individuals also performed worse on one out of 14 measures of neuropsychological function. CONCLUSION: On the whole, there was little evidence that T. gondii was related to increased risk of psychiatric disorder, poor impulse control, personality aberrations or neurocognitive impairment.