2017/12/01 by Elena Cravedi, Emmanuelle Deniau, Marianna Giannitelli +3 · 2 citations
Psychology · Neuroscience · Medicine · #Obsessive-Compulsive Spectrum Disorders #Autism Spectrum Disorder Research #Child Nutrition and Feeding Issues #Neurodevelopmental disorder #Tourette syndrome #Comorbidity #Autism spectrum disorder #Autism #Psychiatry #Tics #Attention deficit #Etiology #Psychology #Attention deficit hyperactivity disorder #Neuropsychology #Intellectual disability #Medicine #Cognition
paper · pdf · doi:10.1186/s13034-017-0196-x
openalex publication_date 2017/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Gilles de la Tourette syndrome (TS) is a complex developmental neuropsychiatric condition in which motor manifestations are often accompanied by comorbid conditions that impact the patient's quality of life. In the DSM-5, TS belongs to the "neurodevelopmental disorders" group, together with other neurodevelopmental conditions, frequently co-occurring. In this study, we searched the PubMed database using a combination of keywords associating TS and all neurodevelopmental diagnoses. From 1009 original reports, we identified 36 studies addressing TS and neurodevelopmental comorbidities. The available evidence suggests the following: (1) neurodevelopmental comorbidities in TS are the rule, rather than the exception; (2) attention deficit/hyperactivity disorder (ADHD) is the most frequent; (3) there is a continuum from a simple (TS + ADHD or/and learning disorder) to a more complex phenotype (TS + autism spectrum disorder). We conclude that a prompt diagnosis and a detailed description of TS comorbidities are necessary not only to understand the aetiological basis of neurodevelopmental disorders but also to address specific rehabilitative and therapeutic approaches.