Malawi Polyomavirus Is a Prevalent Human Virus That Interacts with Known Tumor Suppressors

2014/10/16 by Christian Berrios, Joonil Jung, Blake Primi +8 · 3 citations
Medicine · Agricultural and Biological Sciences · Engineering · #Polyomavirus and related diseases #Plant Virus Research Studies #Full-Duplex Wireless Communications

paper · pdf · doi:10.1128/jvi.02328-14

openalex publication_date 2014/10/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.

Citations

• Merkel Cell Polyomavirus and Two Previously Unknown Polyomaviruses Are Chronically Shed from Human Skin
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• Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
• Human Polyomavirus Related to African Green Monkey Lymphotropic Polyomavirus
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• Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
• Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient
• Identification of MW Polyomavirus, a Novel Polyomavirus in Human Stool

Cited by

• Seroepidemiology of Human Polyomaviruses in a US Population
• Seroprevalence rates of HPyV6, HPyV7, TSPyV, HPyV9, MWPyV and KIPyV polyomaviruses among the healthy blood donors
• MW polyomavirus [wikipedia]

Related

• Seroprevalence of Human Malawi Polyomavirus
• Identification of MW Polyomavirus, a Novel Polyomavirus in Human Stool
• A Novel Human Polyomavirus Closely Related to the African Green Monkey-Derived Lymphotropic Polyomavirus
• The novel human polyomaviruses HPyV6, 7, 9 and beyond
• The human polyomaviruses: from orphans and mutants to patchwork family