2017/04/27 by Can Dincer, Richard C. Bruch, André Kling +2 · 1 citation
Engineering · Biochemistry, Genetics and Molecular Biology · #Biosensors and Analytical Detection #Microfluidic and Capillary Electrophoresis Applications #Advanced Biosensing Techniques and Applications
paper · pdf · doi:10.1016/j.tibtech.2017.03.013
openalex publication_date 2017/04/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors' offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead- or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches.