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Zika virus: a previously slow pandemic spreads rapidly through the Americas

2015/12/18 by Derek Gatherer, Alain Kohl · 8 citations
Medicine · Social Sciences · #Mosquito-borne diseases and control #Viral Infections and Vectors #Dengue and Mosquito Control Research

paper · doi:10.1099/jgv.0.000381

openalex publication_date 2015/12/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

Zika virus (family Flaviviridae) is an emerging arbovirus. Spread by Aedes mosquitoes, it was first discovered in Uganda in 1947, and later in humans elsewhere in sub-Saharan Africa, arriving in south-east Asia at latest by the mid-twentieth century. In the twenty-first century, it spread across the Pacific islands reaching South America around 2014. Since then it has spread rapidly northwards reaching Mexico in November 2015. Its clinical profile is that of a dengue-like febrile illness, but associations with Guillain-Barré syndrome and microcephaly have appeared recently. The final geographical range and ultimate clinical impact of Zika virus are still a matter for speculation.

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