Proteases Acting on Mutant Huntingtin Generate Cleaved Products that Differentially Build Up Cytoplasmic and Nuclear Inclusions

2002/08/01 by Astrid Lunkes, Katrin S. Lindenberg, Léa Ben-Haı̈em +8 · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Genetic Neurodegenerative Diseases #Mitochondrial Function and Pathology #Muscle Physiology and Disorders

paper · pdf · doi:10.1016/s1097-2765(02)00602-0

crossref issued 2002/08/01 · crossref published 2002/08/01 · crossref published-print 2002/08/01 · openalex publication_date 2002/08/01 · crossref created 2004/04/21 · crossref deposited 2019/02/10 · openalex created_date 2025/10/10 · crossref indexed 2026/07/29 · openalex updated_date 2026/08/01

Citations

• The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
• A YAC Mouse Model for Huntington’s Disease with Full-Length Mutant Huntingtin, Cytoplasmic Toxicity, and Selective Striatal Neurodegeneration

Cited by

• A Protein Interaction Network Links GIT1, an Enhancer of Huntingtin Aggregation, to Huntington's Disease
• Bernhard Landwehrmeyer [wikipedia]