A Protein Interaction Network Links GIT1, an Enhancer of Huntingtin Aggregation, to Huntington's Disease

2004/09/01 by Heike Goehler, Maciej Łałowski, Maciej Lalowski +26 · 460 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Biology #Cell biology #Computational biology #Disease #Enhancer #Function (biology) #Fungal and yeast genetics research #Gene #Genetic Neurodegenerative Diseases #Genetics #Huntingtin #Huntingtin Protein #Huntington's disease #Mitochondrial Function and Pathology #Plasma protein binding #Protein–protein interaction #Transcription factor

paper · pdf · doi:10.1016/j.molcel.2004.09.016

published in Molecular Cell 15(6), 853-865 (Elsevier BV)

crossref issued 2004/09/01 · crossref published 2004/09/01 · crossref published-print 2004/09/01 · openalex publication_date 2004/09/01 · crossref created 2004/09/24 · openalex created_date 2025/10/10 · crossref deposited 2025/10/22 · crossref indexed 2026/06/30 · openalex updated_date 2026/07/15

Citations

• The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
• Proteases Acting on Mutant Huntingtin Generate Cleaved Products that Differentially Build Up Cytoplasmic and Nuclear Inclusions

Cited by

• Opposing roles for GSK3β and ERK1-dependent phosphorylation of huntingtin during neuronal dysfunction and cell death in Huntington’s disease
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• Bernhard Landwehrmeyer [wikipedia]