1998/05/08 by Monika Fellermeier, Meinhart H. Zenk · 3 citations
Medicine · Agricultural and Biological Sciences · #Cannabis and Cannabinoid Research #GABA and Rice Research #Sirtuins and Resveratrol in Medicine
paper · pdf · doi:10.1016/s0014-5793(98)00450-5
openalex publication_date 1998/05/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
A new enzyme, geranylpyrophosphate:olivetolate geranyltransferase (GOT), the first enzyme in the biosynthesis of cannabinoids could be detected in extracts of young leaves of Cannabis sativa. The enzyme accepts geranylpyrophosphate (GPP) and to a lesser degree also nerylpyrophosphate (NPP) as a cosubstrate. It is, however, specific for olivetolic acid; its decarboxylation product olivetol is inactive as a prenyl acceptor.