2014/04/16 by Sylvain Baize, Delphine Pannetier, Lisa Oestereich +28 · 16 citations
Medicine · #Viral Infections and Outbreaks Research #Viral Infections and Vectors #Mosquito-borne diseases and control
paper · pdf · doi:10.1056/nejmoa1404505
openalex publication_date 2014/04/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.