2009/10/29 by Chen Li, Dongho Lee, Tyler N. Graf +12 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Traditional and Medicinal Uses of Annonaceae #Phytochemical compounds biological activities #Natural product bioactivities and synthesis
paper · doi:10.1021/np900572g
openalex publication_date 2009/10/29 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.