2005/11/18 by Chen Li, Dongho Lee, Tyler N. Graf +13 · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Annonaceae #Antimicrobial #Biochemistry #Biology #Botany #Cancer #Cancer cell #Cancer cell lines #Chemistry #Cytotoxicity #Diterpene #In vitro #Ketone #Organic chemistry #Oxetane #Phytochemical compounds biological activities #Phytochemistry and Bioactive Compounds #Ring (chemistry) #Stereochemistry #Terpenoid #Traditional and Medicinal Uses of Annonaceae
paper · doi:10.1021/ol052498l
openalex publication_date 2005/11/18 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
[chemical reaction: see text]. Three new ent-trachylobane diterpenoids (1-3) were isolated and structures elucidated from Mitrephora glabra Scheff. (Annonaceae). Mitrephorone A (1) possesses a hexacyclic ring system with adjacent ketone moieties and an oxetane ring, both of which are unprecedented among trachylobanes. All compounds were evaluated for cytotoxicity against a panel of cancer cells, where 1 displayed the most potent and broadest activity, and against a battery of antimicrobial assays, where all compounds were approximately equipotent.