2021/09/10 by Sabiha Shaik, Arya Suresh, Niyaz Ahmed · 1 citation
Biochemistry, Genetics and Molecular Biology · #Antibiotic Resistance in Bacteria #Gut microbiota and health #Bacterial Identification and Susceptibility Testing
paper · pdf · doi:10.1093/infdis/jiab456
openalex publication_date 2021/09/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
Genomics-driven molecular epidemiology of pathogenic bacteria has largely been carried out through functionally neutral/inert sequences, mostly entailing polymorphic gene loci or repetitive tracts. However, it is very important to harness phenotypically relevant markers to assign a valid functional epidemiological context to tracking of pathogens. These should include microbial acumen to acquire multiple drug resistance (MDR), their physiological coordinates with reference to clinical or community-level dynamics of incidence/transmission, and their response or refractoriness to the activated immune system. We propose that multidimensional and multicentric approaches, based on diverse data integration coupled with comparative genomics and functional molecular infection epidemiology, would likely be successful in tracking the emergence and spread of MDR pathogens and thereby guiding the global infection control strategies in a highly informed manner.