Mobile Genetic Elements Associated with Antimicrobial Resistance

2018/10/01 by Sally R. Partridge, Stephen M. Kwong, Neville Firth +1 · 7 citations

paper · doi:10.1128/cmr.00088-17

Abstract

Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an increasing major health care problem around the world. It is now abundantly clear that both Gram-negative and Gram-positive bacteria are able to meet the evolutionary challenge of combating antimicrobial chemotherapy, often by acquiring preexisting resistance determinants from the bacterial gene pool.

Cited by

• Impacts of mobile genetic elements on antimicrobial resistance genes in gram-negative pathogens: Current insights and genomic approaches
• Clinical Rel mutations that increase basal (p)ppGpp promote conjugal transfer of staphylococcal resistance plasmids
• Reconstructing the Network of Horizontal Gene Exchange in Bacteria to Differentiate Direct and Indirect Transfers
• Beyond borders: plasmids drive a shared antibiotic resistome in European urban water systems
• Metagenomic profiling of airborne microbial communities from aircraft filters and face masks
• Hybrid sequencing of chromosome and plasmids from multidrug-resistant Escherichia coli isolated in Cambodia: Are megaplasmids vectors of antibiotic resistance genes?
• The extended mobility of plasmids

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• The Scourge of Antibiotic Resistance: The Important Role of the Environment
• Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It
• Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World?
• Combining mutation and horizontal gene transfer in a within-host model of antibiotic resistance
• The Spread of Antibiotic Resistance Is Driven by Plasmids Among the Fastest Evolving and of Broadest Host Range