The <b><i>Anopheles</i></b> Innate Immune System in the Defense against Malaria Infection

2013/08/28 by April M. Clayton, Yuemei Dong, George Dimopoulos · 1 citation
Immunology and Microbiology · Agricultural and Biological Sciences · #Invertebrate Immune Response Mechanisms #Insect Utilization and Effects #Insect symbiosis and bacterial influences

paper · pdf · doi:10.1159/000353602

openalex publication_date 2013/08/28 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Abstract

The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.

Cited by

• Plasmodium berghei [wikipedia]

Related

• Mosquito immunity and its defense against malaria parasite
• Innate Cellular Immune Responses inAedes caspius(Diptera: Culicidae) Mosquitoes
• The Plasmodium bottleneck: malaria parasite losses in the mosquito vector
• Comparison of innate immune responses against arboviruses in mammalian hosts and mosquito vectors
• The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes