2014/04/28 by Ryan C. Smith, Joel Vega-Rodríguez, Marcelo Jacobs‐Lorena · 1 citation
Immunology and Microbiology · Agricultural and Biological Sciences · Medicine · #Invertebrate Immune Response Mechanisms #Insect symbiosis and bacterial influences #Mosquito-borne diseases and control
paper · pdf · doi:10.1590/0074-0276130597
openalex publication_date 2014/04/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.