Estrogen receptors and human disease

2006/03/01 by Bonnie J. Deroo · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Bioinformatics #Biology #Breast cancer #Cancer #Disease #Endocrinology #Endometriosis #Estrogen #Estrogen and related hormone effects #Estrogen receptor #Estrogen receptor alpha #Insulin resistance #Internal medicine #Medicine #Menopause: Health Impacts and Treatments #Obesity #Osteoporosis #Prostate cancer #Sex and Gender in Healthcare

paper · pdf · doi:10.1172/jci27987

openalex publication_date 2006/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Estrogens influence many physiological processes in mammals, including but not limited to reproduction, cardiovascular health, bone integrity, cognition, and behavior. Given this widespread role for estrogen in human physiology, it is not surprising that estrogen is also implicated in the development or progression of numerous diseases, which include but are not limited to various types of cancer (breast, ovarian, colorectal, prostate, endometrial), osteoporosis, neurodegenerative diseases, cardiovascular disease, insulin resistance, lupus erythematosus, endometriosis, and obesity. In many of these diseases, estrogen mediates its effects through the estrogen receptor (ER), which serves as the basis for many therapeutic interventions. This Review will describe diseases in which estrogen, through the ER, plays a role in the development or severity of disease.

Citations

• Obesity and Disturbed Lipoprotein Profile in Estrogen Receptor-α-Deficient Male Mice
• Molecular Determinants for the Tissue Specificity of SERMs
• Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation
• Evaluation of an Estrogen Receptor-β Agonist in Animal Models of Human Disease
• Selective Estrogen-Receptor Modulators for Primary Prevention of Breast Cancer
• Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
• Understanding the Divergent Data on Postmenopausal Hormone Therapy
• Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
• Expression and Localization of Estrogen Receptor-β in Murine and Human Bone
• Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

Cited by

• Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms
• The G-protein-coupled estrogen receptor GPER in health and disease
• Structure-Based Approach for the Discovery of Novel Selective Estrogen Receptor Modulators
• Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury
• Estrogen receptor beta and ovarian cancer: a key to pathogenesis and response to therapy
• Estrogen Receptors: Their Actions and Functional Roles in Health and Disease
• New insights into the molecular mechanisms underlying effects of estrogen on cholesterol gallstone formation
• Estrogen receptor [wikipedia]