Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

2010/01/24 by Stefan Stein, Marion G Ott, Marion Ott +29 · 4 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Biology #Cancer research #Chromosome #Chronic granulomatous disease #Gene #Gene silencing #Genetic enhancement #Genetics #Genome instability #Immunology #Internal medicine #Medicine #Monosomy #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Telomeres, Telomerase, and Senescence #Transplantation #Virus-based gene therapy research

paper · pdf · doi:10.1038/nm.2088

crossref issued 2010/01/24 · crossref published 2010/01/24 · crossref published-online 2010/01/24 · openalex publication_date 2010/01/24 · crossref created 2010/01/24 · crossref published-print 2010/02/01 · crossref deposited 2023/05/18 · openalex created_date 2025/10/10 · crossref indexed 2026/07/26 · openalex updated_date 2026/08/04

Citations

• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139
• Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
• Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Cited by

• Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease
• Lentiviral Vector Gene Therapy: Effective and Safe?
• Gene therapy clinical trials worldwide to 2012 – an update
• Lentiviral vector in gene therapy [wikipedia]