2018/05/23 by Gonca Bayraktar, Michael R. Kreutz · 1 citation
Biochemistry, Genetics and Molecular Biology · Social Sciences · #Epigenetics and DNA Methylation #Genetics and Neurodevelopmental Disorders #Family Support in Illness
paper · pdf · doi:10.3389/fnmol.2018.00169
openalex publication_date 2018/05/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.