2016/03/01 by Zhiqin Wang, Beisha Tang, Yuquan He +1 · 4 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Epigenetics and DNA Methylation #Neurogenesis and neuroplasticity mechanisms #Genetics and Neurodevelopmental Disorders
paper · doi:10.2217/epi.15.119
openalex publication_date 2016/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Neurogenesis is not limited to the embryonic stage, but continually proceeds in the adult brain throughout life. Epigenetic mechanisms, including DNA methylation, histone modification and noncoding RNA, play important roles in neurogenesis. For decades, DNA methylation was thought to be a stable modification, except for demethylation in the early embryo. In recent years, DNA methylation has proved to be dynamic during development. In this review, we summarize the latest understanding about DNA methylation dynamics in neurogenesis, including the roles of different methylation forms (5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine), as well as their 'writers', 'readers' and interactions with histone modifications.