2011/09/02 by Derrek A. Heuveling, Gerard W.M. Visser, Marian Baclayon +6 · 1 citation
Medicine · #Head and Neck Cancer Studies #Radiopharmaceutical Chemistry and Applications #Esophageal Cancer Research and Treatment
paper · pdf · doi:10.2967/jnumed.111.089557
openalex publication_date 2011/09/02 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01
UNLABELLED: Identifying sentinel nodes near the primary tumor remains a problem in, for example, head and neck cancer because of the limited resolution of current lymphoscintigraphic imaging when using (99m)Tc-nanocolloidal albumin. This study describes the development and evaluation of a nanocolloidal albumin-based tracer specifically dedicated for high-resolution PET detection. METHODS: (89)Zr was coupled to nanocolloidal albumin via the bifunctional chelate p-isothiocyanatobenzyldesferrioxamine B. Quality control tests, including particle size measurements, and in vivo biodistribution and imaging experiments in a rabbit lymphogenic metastasis model were performed. RESULTS: Coupling of (89)Zr to nanocolloidal albumin appeared to be efficient, resulting in a stable product with a radiochemical purity greater than 95%, without affecting the particle size. PET showed distinguished uptake of (89)Zr-nanocolloidal albumin in the sentinel nodes, with visualization of lymphatic vessels, and with a biodistribution comparable to (99m)Tc-nanocolloidal albumin. CONCLUSION: (89)Zr-nanocolloidal albumin is a promising tracer for sentinel node detection by PET.