2012/01/15 by Yongjian Liu, Michael J. Welch
Biochemistry, Genetics and Molecular Biology · Materials Science · Medicine · #Advanced biosensing and bioanalysis techniques #Nanoparticle-Based Drug Delivery #Radiopharmaceutical Chemistry and Applications
paper · doi:10.1021/bc200264c
openalex publication_date 2012/01/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Over the past decade, positron emitter labeled nanoparticles have been widely used in and substantially improved for a range of diagnostic biomedical research. However, given growing interest in personalized medicine and translational research, a major challenge in the field will be to develop disease-specific nanoprobes with facile and robust radiolabeling strategies and that provide imaging stability, enhanced sensitivity for disease early stage detection, optimized in vivo pharmacokinetics for reduced nonspecific organ uptake, and improved targeting for elevated efficacy. This review briefly summarizes the major applications of nanoparticles labeled with positron emitters for cardiovascular imaging, lung diagnosis, and tumor theranostics.