The Chemodiversity of Purine as a Constituent of Natural Products

2004/03/01 by Helmut Rosemeyer · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Biochemical and Molecular Research #HIV/AIDS drug development and treatment #Chemical Reaction Mechanisms

paper · doi:10.1002/cbdv.200490033

openalex publication_date 2004/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26

Abstract

In this review, I describe various natural manifestations of purine systems, i.e., methylated, higher-alkylated, and glycosylated forms. These comprise the purine alkaloids, cytokines, as well as the purine nucleoside antibiotics. In part, the compounds described herein were isolated from natural sources already long ago. However, some have been reported only during the last few years. The biological activities of most of the purine derivatives are briefly described, and, in some cases, syntheses are formulated. In particular, this article introduces the main synthetic principles for the generation of the purine ring system. The last chapter describes modern preparative routes for C-alkylation and C-arylation of purines.

Citations

• Amino-acid Synthesis from Hydrogen Cyanide under Possible Primitive Earth Conditions
• Structure of discadenine, a spore germination inhibitor from the cellular slime mold,
• Photochemical Reactions and the Chemical Evolution of Purines and Nicotinamide Derivatives
• A One-step Synthesis of Purine Ring from Formamide
• The diversity of naturally occurring organobromine compounds
• Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
• An Unusual Photochemical Rearrangement in the Synthesis of Adenine from Hydrogen Cyanide1

Cited by

• Pyrimidine as Constituent of Natural Biologically Active Compounds
• Purine [wikipedia]