2015/01/01 by Marek L. Kowalski, Joanna Makowska · 1 citation
Medicine · #Adverse effect #Allergy #Anaphylaxis #Dermatology #Drug-Induced Adverse Reactions #Hypersensitivity reaction #Immunology #Inflammatory mediators and NSAID effects #Intensive care medicine #Irritation #Mechanism (biology) #Medicine #Pharmacology #Urticaria and Related Conditions
paper · pdf · doi:10.4168/aair.2015.7.4.312
openalex publication_date 2015/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) has been paralleled by increasing occurrence of adverse reactions, which vary from mild local skin rashes or gastric irritation to severe, generalized symptoms and even life-threatening anaphylaxis. NSAID-induced hypersensitivity reactions may involve both immunological and non-immunological mechanisms and should be differentiated from type A adverse reactions. Clinical diagnosis and effective management of a hypersensitive patient cannot be achieved without identifying the underlying mechanism. In this review, we discuss the current classification of NSAID-induced adverse reactions and propose a practical diagnostic algorithm that involves 7 steps leading to the determination of the type of NSAID-induced hypersensitivity and allows for proper patient management.