Drug Delivery Systems: Entering the Mainstream

2004/03/19 by Theresa M. Allen, Pieter R. Cullis · 4 citations
Materials Science · Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Nanoparticle-Based Drug Delivery #RNA Interference and Gene Delivery #Advanced Drug Delivery Systems

paper · doi:10.1126/science.1095833

openalex publication_date 2004/03/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.

Citations

• Ligand-targeted therapeutics in anticancer therapy
• Small-scale systems for in vivo drug delivery

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