2011/02/16 by Moorthi Chidambaram, R. Manavalan, K. Kathiresan · 1 citation
Chemistry · Materials Science · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Advanced Drug Delivery Systems #Antibiotics #Aqueous solution #Bioavailability #Biochemistry #Biology #Cancer #Cancer cell #Chemistry #Chemosensitizer #Chemotherapy #Drug Transport and Resistance Mechanisms #Drug delivery #Drug resistance #Internal medicine #Liposome #Materials science #Medicine #Mesoporous silica #Micelle #Multiple drug resistance #Nanomedicine #Nanoparticle #Nanoparticle-Based Drug Delivery #Nanotechnology #Organic chemistry #Pharmacology #Poloxamer #Polymer #Solid lipid nanoparticle
paper · pdf · doi:10.18433/j30c7d
openalex publication_date 2011/02/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy.