1995/10/01 by David A. Fell, Simon Thomas · 3 citations
Biochemistry, Genetics and Molecular Biology · #Amino Acid Enzymes and Metabolism #Mitochondrial Function and Pathology #Hemoglobin structure and function
paper · pdf · doi:10.1042/bj3110035
openalex publication_date 1995/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.