Die Harmonisierung des Europäischen Kapitalmarktrechts und das Recht des Wertpapierhandels in Italien und in Deutschland

1986/08/01 by Gray D. Shaw, Robert Kamen, Andreas Kaiser · 6 citations
Biochemistry, Genetics and Molecular Biology · Business, Management and Accounting · Economics, Econometrics and Finance · #Corporate Governance and Law #RNA Interference and Gene Delivery #RNA Research and Splicing #RNA and protein synthesis mechanisms #Taxation and Legal Issues #finance, banking, and market dynamics

paper · doi:10.1016/0092-8674(86)90341-7

openalex publication_date 1996/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/04/28

Abstract

The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51 nucleotide AT sequence from a human lymphokine gene, GM-CSF, into the 3' untranslated region of the rabbit beta-globin gene. Our experiments demonstrate that this caused the otherwise stable beta-globin mRNA to become highly unstable in vivo. The instability conferred by the AU sequence in the mRNA was partially alleviated by treatment of the cells with cycloheximide. We propose that the AU sequences are the recognition signal for an mRNA processing pathway which specifically degrades the mRNAs for certain lymphokines, cytokines, and proto-oncogenes.

Citations

• Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

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• Messenger RNA [wikipedia]