2019/01/01 by O. S. Kostareva, Olga Kostareva, A. G. Gabdulkhakov +7 · 29 citations
Immunology and Microbiology · Medicine · #Arthritis #Autoimmune and Inflammatory Disorders Research #Cytokine #Cytokine Signaling Pathways and Interactions #Immunology #Medicine #Psoriasis #Psoriasis: Treatment and Pathogenesis #Rheumatoid arthritis
paper · doi:10.1134/s0006297919140116
published in Biochemistry (Moscow) 84(S1), 193-205 (Pleiades Publishing)
crossref issued 2019/01/01 · crossref published 2019/01/01 · crossref published-print 2019/01/01 · openalex publication_date 2019/01/01 · crossref published-online 2019/04/19 · crossref created 2019/04/19 · openalex created_date 2025/10/10 · crossref deposited 2026/03/16 · crossref indexed 2026/07/28 · openalex updated_date 2026/07/31
Cytokines of the IL-17 family play a key role in the host organism defense against bacterial and fungal infections. At the same time, upregulated synthesis of IL-17 cytokines is associated with immunoinflammatory and autoimmune diseases such as psoriasis, rheumatoid arthritis, systemic lupus erythematosus, and others. The members of this family are important therapeutic targets in the treatment of various human chronic inflammatory disorders. Elucidation of signaling pathways involving IL-17 family proteins and analysis of the structure of cytokine complexes with specific antibodies, inhibitors, and receptors are essential for the development of new drugs for the therapy of immunoinflammatory rheumatic diseases.