Mitochondrial Metabolism and Cancer

2009/10/01 by Frank Weinberg, Navdeep S. Chandel · 1 citation
Biochemistry, Genetics and Molecular Biology · #Cancer, Hypoxia, and Metabolism #Mitochondrial Function and Pathology #Metabolomics and Mass Spectrometry Studies

paper · doi:10.1111/j.1749-6632.2009.05039.x

openalex publication_date 2009/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Historically, it has been assumed that glycolytic metabolism, not mitochondrial metabolism, is essential for tumor cell proliferation. However, most tumor cells have functional mitochondria, and recent studies suggest that the citric acid cycle (TCA) cycle intermediates are precursors for synthesis of nucleotides, lipids, and amino acids. Here we review the accumulating evidence that mitochondrial metabolism plays an essential role in tumor cell proliferation.

Citations

• Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
• The Hallmarks of Cancer
• HIF-1 mediates the Warburg effect in clear cell renal carcinoma
• On the Origin of Cancer Cells
• HIF-1 and human disease: one highly involved factor
• TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Cited by

• Mitochondria [wikipedia]

Related

• Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change
• Targeting the Mitochondrial Metabolic Network: A Promising Strategy in Cancer Treatment
• Cancer as a mitochondrial metabolic disease
• Cancer as a metabolic disease: implications for novel therapeutics
• Mitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis