2015/07/07 by Thomas N. Seyfried · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Mitochondrial Function and Pathology #Cancer, Hypoxia, and Metabolism #Genomics and Rare Diseases #Somatic cell #Mutation #Biology #Disease #Mitochondrion #Mitochondrial DNA #Cancer #Genetics #Mitochondrial disease #Warburg effect #Germline mutation #Gene #Cancer cell #Medicine #Pathology
paper · pdf · doi:10.3389/fcell.2015.00043
openalex publication_date 2015/07/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Cancer is widely considered a genetic disease involving nuclear mutations in oncogenes and tumor suppressor genes. This view persists despite the numerous inconsistencies associated with the somatic mutation theory. In contrast to the somatic mutation theory, emerging evidence suggests that cancer is a mitochondrial metabolic disease, according to the original theory of Otto Warburg. The findings are reviewed from nuclear cytoplasm transfer experiments that relate to the origin of cancer. The evidence from these experiments is difficult to reconcile with the somatic mutation theory, but is consistent with the notion that cancer is primarily a mitochondrial metabolic disease.